LIPOSOMES - ANTICANCER DRUGS - ANTIVIRAL DRUGS - CONTRAST AGENTS - CLINICAL TRIALS

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The Laboratory of Liposome Research

Clinical Applications of Liposomal Drug Formulations

  • Development of large batches of liposomes for clinical applications: Preparation of liposomes by detergent dialysis.
  • Phase I and II trials with liposomal antitumor drugs:
  • Phase I study with liposomal Mitoxantrone in breast cancer patients
  • Phase II study with liposomal Mitoxantrone in breast cancer patients
  • Phase I study with liposomal Mitoxantrone in dogs (in collaboration with the Veterinary Clinics of the University, Dr. D. Ruslander)

Literature References:
  • Schwendener, R.A., The Preparation of large Volumes of homogeneous, sterile Liposomes containing various lipophilic cytostatic Drugs by the Use of a Capillary Dialyzer. Cancer Drug Delivery 3 (2), 123-129 (1986).

  • Pestalozzi, B., Schwendener, R.A., Sauter, Ch.,Phase I/II Study of Liposome-complexed Mitoxantrone in Patients with advanced Breast Cancer. Ann. Oncol. 3, 445-449 (1992).

  • Schwendener, R. The Preparation of large Volumes of sterile Liposomes for clinical Applications. In: Liposome Technology, 2.Ed. (Ed. G.Gregoriadis) CRC Press 1993, p. 487-500.

  • Schwendener, R.A., Horber, D.H., Rentsch, K., Hänseler, E., Pestalozzi, B., and Sauter, Chr. Preclinical and clinical Experience with Liposome-encapsulated Mitoxantrone. J. Liposome Res. 4, 605-639 (1994).

  • B.C. Pestalozzi, A. Vass, H. Adam, D.H. Horber, R.A. Schwendener and C. Sauter. Phase II Study of liposome-complexed Mitoxantrone in Patients with advanced Breast Cancer. Eur. J. Cancer, 31A: 1024 (1995).

  • Rentsch, K.M., Schwendener, R.A., Pestalozzi, B.C., Sauter, Ch., Wunderli-Allenspach, H., Hänseler, E.Pharmacokinetic studies of mitoxantrone and one of its metabolites in serum and urine in patients with advanced breast cancer. Eur. J. Clin. Pharmacol.,54: 83-89 (1998).

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LIPOSOMES - ANTICANCER DRUGS - ANTIVIRAL DRUGS - CONTRAST AGENTS - CLINICAL TRIALS