Publications

ZORA Publication List

Publications

• 2023

  • Journal Article

    • Moro, Ramona N; Biswas, Uddipta; Kharat, Suhas S; Duzanic, Filip D; Das, Prosun; Stavrou, Maria; Raso, Maria C; Freire, Raimundo; Chaudhuri, Arnab Ray; Sharan, Shyam K; Penengo, Lorenza (2023). Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15. Nature Communications, 14(1):6140.

• 2021

  • Journal Article

    • Mattiroli, Francesca; Penengo, Lorenza (2021). Histone Ubiquitination: An Integrative Signaling Platform in Genome Stability. Trends in Genetics : Tig, 37(6):566-581.

• 2020

  • Journal Article

    • Walser, Franziska; Mulder, Monique P C; Bragantini, Benoît; Burger, Sibylle; Gubser, Tatiana; Gatti, Marco; Botuyan, Maria Victoria; Villa, Alessandra; Altmeyer, Matthias; Neri, Dario; Ovaa, Huib; Mer, Georges; Penengo, Lorenza (2020). Ubiquitin phosphorylation at Thr12 modulates the DNA damage response. Molecular Cell, 80(3):423-436.e9.
    • Raso, Maria Chiara; Djoric, Nikola; Walser, Franziska; Hess, Sandra; Schmid, Fabian Marc; Burger, Sibylle; Knobeloch, Klaus-Peter; Penengo, Lorenza (2020). Interferon-stimulated gene 15 accelerates replication fork progression inducing chromosomal breakage. Journal of Cell Biology, 219(8):1-21.
    • Okonska, Agata; Bühler, Saskja; Rao, Vasundhara; Ronner, Manuel; Blijlevens, Maxime; van der Meulen-Muileman, Ida H; de Menezes, Renée X; Wipplinger, Martin; Oehl, Kathrin; Smit, Egbert F; Weder, Walter; Stahel, Rolf A; Penengo, Lorenza; van Beusechem, Victor W; Felley-Bosco, Emanuela (2020). Functional genomic screen in mesothelioma reveals that loss of function of BRCA1-associated-protein-1 induces chemoresistance to ribonucleotide reductase inhibition. Molecular Cancer Therapeutics, 19(2):552-563.

• 2018

  • Journal Article

    • Squarzanti, Diletta Francesca; Sorrentino, Rita; Landini, Manuela Miriam; Chiesa, Andrea; Pinato, Sabrina; Rocchio, Francesca; Mattii, Martina; Penengo, Lorenza; Azzimonti, Barbara (2018). Human papillomavirus type 16 E6 and E7 oncoproteins interact with the nuclear p53-binding protein 1 in an in vitro reconstructed 3D epithelium: new insights for the virus-induced DNA damage response. Virology Journal, 15(1):176.
    • Schmid, Jonas Andreas; Berti, Matteo; Walser, Franziska; Raso, Maria Chiara; Schmid, Fabian; Krietsch, Jana; Stoy, Henriette; Zwicky, Katharina; Ursich, Sebastian; Freire, Raimundo; Lopes, Massimo; Penengo, Lorenza (2018). Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase. Molecular Cell, 71(6):897-910.e8.

• 2017

  • Journal Article

    • Balbo Pogliano, Chiara; Gatti, Marco; Rüthemann, Peter; Garajovà, Zuzana; Penengo, Lorenza; Naegeli, Hanspeter (2017). ASH1L histone methyltransferase regulates the handoff between damage recognition factors in global-genome nucleotide excision repair. Nature Communications, 8(1):1333.
    • Vujanovic, Marko; Krietsch, Jana; Raso, Maria Chiara; Terraneo, Nastassja; Zellweger, Ralph; Schmid, Jonas A; Taglialatela, Angelo; Huang, Jen-Wei; Holland, Cory L; Zwicky, Katharina; Herrador, Raquel; Jacobs, Heinz; Cortez, David; Ciccia, Alberto; Penengo, Lorenza; Lopes, Massimo (2017). Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity. Molecular Cell, 67(5):882-890.e5.
    • Graf, Urs; Casanova, Elisa A; Wyck, Sarah; Dalcher, Damian; Gatti, Marco; Vollenweider, Eva; Okoniewski, Michal J; Weber, Fabienne A; Patel, Sameera S; Schmid, Marc W; Li, Jiwen; Sharif, Jafar; Wanner, Guido A; Koseki, Haruhiko; Wong, Jiemin; Pelczar, Pawel; Penengo, Lorenza; Santoro, Raffaella; Cinelli, Paolo (2017). Corrigendum: Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways. Nature Cell Biology, 19(8):1003.
    • Graf, Urs; Casanova, Elisa A; Wyck, Sarah; Dalcher, Damian; Gatti, Marco; Vollenweider, Eva; Okoniewski, Michal J; Weber, Fabienne A; Patel, Sameera S; Schmid, Marc W; Li, Jiwen; Sharif, Jafar; Wanner, Guido A; Koseki, Haruhiko; Wong, Jiemin; Pelczar, Pawel; Penengo, Lorenza; Santoro, Raffaella; Cinelli, Paolo (2017). Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways. Nature Cell Biology, 19(7):763-773.
    • Parrotta, Rossella; Okonska, Agata; Ronner, Manuel; Weder, Walter; Stahel, Rolf; Penengo, Lorenza; Felley-Bosco, Emanuela (2017). A novel BRCA1-associated protein-1 isoform affects response of mesothelioma cells to drugs impairing BRCA1-mediated DNA repair. Journal of Thoracic Oncology, 12(8):1309-1319.

• 2015

  • Journal Article

    • Gatti, Marco; Pinato, Sabrina; Maiolica, Alessio; Rocchio, Francesca; Prato, Maria Giulia; Aebersold, Ruedi; Penengo, Lorenza (2015). RNF168 promotes noncanonical K27 ubiquitination to signal DNA damage. Cell Reports, 10(2):226-38.

• 2014

  • Journal Article

    • Maiolica, Alessio; de Medina-Redondo, Maria; Schoof, Erwin M; Chaikuad, Apirat; Villa, Fabrizio; Gatti, Marco; et al; Penengo, Lorenza (2014). Modulation of the chromatin phosphoproteome by the Haspin protein kinase. Molecular & Cellular Proteomics, 13(7):1724-1740.

• 2012

  • Journal Article

    • Gatti, Marco; Pinato, Sabrina; Maspero, Elena; Soffientini, Paolo; Polo, Simona; Penengo, Lorenza (2012). A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase. Cell Cycle, 11(13):2538-2544.

• 2011

  • Journal Article

    • Pinato, Sabrina; Gatti, Marco; Scandiuzzi, Cristina; Confalonieri, Stefano; Penengo, Lorenza (2011). UMI, a novel RNF168 ubiquitin binding domain involved in the DNA damage signaling pathway. Molecular and Cellular Biology, 31(1):118-26.

• 2009

  • Journal Article

    • Pinato, Sabrina; Scandiuzzi, Cristina; Arnaudo, Nadia; Citterio, Elisabetta; Gaudino, Giovanni; Penengo, Lorenza (2009). RNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AX. BMC Molecular Biology, 10:55.

• 2007

  • Journal Article

    • Woelk, Tanja; Sigismund, Sara; Penengo, Lorenza; Polo, Simona (2007). The ubiquitination code: a signalling problem. Cell Division, 2:11.

• 2006

  • Journal Article

    • Germano, Serena; Barberis, Davide; Santoro, Massimo M; Penengo, Lorenza; Citri, Ami; Yarden, Yosef; Gaudino, Giovanni (2006). Geldanamycins trigger a novel Ron degradative pathway, hampering oncogenic signaling. Journal of Biological Chemistry, 281(31):21710-21719.
    • Penengo, Lorenza; Mapelli, Marina; Murachelli, Andrea G; Confalonieri, Stefano; Magri, Laura; Musacchio, Andrea; Di Fiore, Pier Paolo; Polo, Simona; Schneider, Thomas R (2006). Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin. Cell, 124(6):1183-1195.

• 2003

  • Journal Article

    • Penengo, Lorenza; Rubin, Chanan; Yarden, Yosef; Gaudino, Giovanni (2003). c-Cbl is a critical modulator of the Ron tyrosine kinase receptor. Oncogene, 22(24):3669-3679.

• 2001

  • Journal Article

    • Brunelleschi, S; Penengo, Lorenza; Lavagno, L; Santoro, C; Colangelo, D; Viano, I; Gaudino, G (2001). Macrophage stimulating protein (MSP) evokes superoxide anion production by human macrophages of different origin. British Journal of Pharmacology, 134(6):1285-1295.
    • Cacciotti, P; Libener, R; Betta, P; Martini, F; Porta, C; Procopio, A; Strizzi, L; Penengo, Lorenza; Tognon, M; Mutti, L; Gaudino, G (2001). SV40 replication in human mesothelial cells induces HGF/Met receptor activation: a model for viral-related carcinogenesis of human malignant mesothelioma. Proceedings of the National Academy of Sciences of the United States of America, 98(21):12032-12037.

• 2000

  • Journal Article

    • Santoro, M M; Penengo, Lorenza; Orecchia, S; Cilli, M; Gaudino, G (2000). The Ron oncogenic activity induced by the MEN2B-like substitution overcomes the requirement for the multifunctional docking site. Oncogene, 19(45):5208-5211.

• 1998

  • Journal Article

    • Santoro, M M; Penengo, Lorenza; Minetto, M; Orecchia, S; Cilli, M; Gaudino, G (1998). Point mutations in the tyrosine kinase domain release the oncogenic and metastatic potential of the Ron receptor. Oncogene, 17(6):741-749.